A pentacyclic triterpenoid that is lupane having a double bond at position 2029 as well as 3 beta hydroxy and 28carboxy substituents. Pdf betulinic acid and sterols from astragalus altaicus. All ionic liquids were dried for at least 2448 h at room temperature or 50 c and 0. The solubilities of betulinic acid in methanol, ethanol, 1propanol, 2propanol, 1butanol, 2butanol, 1pentanol, 1hexanol, ethyl formate, ethyl acetate, butyl acetate, acetone, and tetrahydrofuran were measured by an analytical method in the temperature range of 278. Cytotoxic conjugates of betulinic acid and substituted. You also can through below form to request documents for moa,ros,1h nmr. Isolation and characterization of lup2029ene3, 28 diol betulin. Betulinic acid view entire compound with free spectra.
Isolation and characterization of triterpenes from the leaves of. A simple preparation of betulinic acid from sycamore bark. Synthetic derivatives of betulinic acid have also been investigated as specific inhibitors of hiv type 1 11. Orthosiphon stamineus, benth, belonging to the family lamiaceae, is a medicinal plant growing wild in tropical countries. Along with antihiv1 and antitumor activity, it also shows other bioactivities such as antiinflammatory, antibacterial, in vitro antimalarial, anthelmintic and antioxidant activities.
H1 nmr were used to identify the structure of betulin and betulinic acid. Pdf synthesis and cytotoxicity of triterpenoids derived. Pdf a simple preparation of betulinic acid from sycamore. In the 1hnmr spectra of these compounds, the esterified products. Betulinic acid is a lupanetype triterpene, which can be prepared from betulin via oxidation using chromium oxide vi. Bioactive oleanane, lupane and ursane triterpene acid derivatives. Antibacterial activities of triterpenoidal compounds isolated from. Pdf the triterpinoids, betulinic acid, lupeol and betulinaldehyde, were. Synthesis and cytotoxicity of triterpenoids derived from betulin and betulinic acid via click chemistry article pdf available in journal of asian natural products research 172. The structures of these compounds have been established by spectroscopic methods. Pdf isolation of betulinic acid from the stem bark and root of. Seven triterpenes, ursolic acid, oleanolic acid, betulinic acid, hydroxybetulinic. Five compounds were isolated and they were betulinic acid 1. The experimental data were correlated with a threeparameter empirical equation and uniquac model, respectively.
Isolation and characterization of triterpenes from the. Solubilities of betulinic acid in thirteen organic. Synthetic approach to analogues of betulinic acid michael e. Seven triterpenes, ursolic acid, oleanolic acid, betulinic acid, hydroxybetulinic acid, maslinic acid. Structures of compounds 14 were determined by analyses of their ir, ms and nmr spectra and comparison of these data with those reported in the literature. You also can through below form to request documents for moa,ros,1hnmr. The structures of these compounds were determined by spectroscopic analysis uv, ir, 1 h nmr, cnmr and eims. Fraction d1 was chromatographed over silica gel using a gradient.
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